Hot melt adhesive compositions containing a polystyrene-polyisoprene/polybutadiene-polystyrene block copolymer and its use in the manufacture of disposable absorbent articles. The adhesive comprises a thermoplastic polystyrene-polyisoprene/polybutadiene- polystyrene block copolymer having a styrene content of at least 25 wt % and a diblock percentage of less than 30 %, a second thermoplastic block copolymer and a tackifier.