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Functionalized polypeptides
专利权人:
David Urech
发明人:
David Urech
申请号:
US13000499
公开号:
US08637022B2
申请日:
2009.06.30
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention provides functionalized polypeptides, especially therapeutic polypeptides (e.g., scFv), comprising a linker sequence that can be rapidly and specifically functionalized by the addition of one or functional moieties (e.g., PEG) or binding specificities (e.g., an amino acid sequence with a particular binding specificity). Such functionalized polypeptides are advantageous in that they have improved pharmacokinetic properties (e.g., improved in vivo half-life, tissue penetration and tissue residency time) over non-functionalized polypeptides. Methods for the rapid and reproducible generation of functionalized polypeptides are also provided.
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