TUCKER CURRAN ROBERTS,PETER ANDREW SMITH,ROBERT I. HIGUCHI,DAVID CAMPBELL,PRASUNA PARASELLI
申请号：
ARP130104303
公开号：
AR093581A1
申请日:
2013.11.21
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Their function is to inhibit the type 1 signal foam (SPSB), which is the basic protein of bacteria. Methods for drug synthesis and treatment using compounds are also provided. 1. Claim 1: a compound characterized by formula (1), wherein: E1 is c8332126；C₂₋₇ alkenyl,1. C 83228331 asphalt；C₃₋₇ cycloalkyl,e. Isopropene, isopropene, isopropene, or arilo；1. C 83228331 asphalt；C₃₋₇ cycloalkyl,Heterosexuality, heterosexuality, or arilo, is a combination, or- yes.-No. 830808--C (O) --C83228O---8-832222--CH S--SCH₂-,-CH₂NR⁴-,-83088ch8322 -,-8308； C (o),-C (o) No. 830808--8308； s (o) 83222 -,-S (O) NR --8308； - 83088；-8308； C (o) O -,-OC (O) NR -O c83218c83318324 is selectively replaced by Oh, CN, no.832222；halogen, C₁₋₆ alkyl；L² is a bond, or optionally substituted C unión alkylene； X is a remainder of the group of formulas (2)；where n4, n5 and n6 are independently of each other 1, 2 or 3； n7 is 0, 1 or 2； R²¹ᵇ and R²²ᵇ are independently hydrogen, hydroxy, C₁₋₆ alkyl in each case,C₃₋₇ cycloalkyl,5-7 membered heteroaryl, 5-7 membered heterocyclyl, or C₆₋₁₀ aryl,Any asphalt, cyclopropyl, isopropyl, isopropyl, arilo or isopropyl can be replaced by 1 to 3 joules； R2 8309es h, O H, ORC, the rest of the formula group (3),or NR²⁵ᵃR²⁵ᵇ where R²⁵ᵃ and R²⁵ᵇ are independently of each other H, SO₂-C₁₋₆ alkyl,or optionally substituted alkyl； RB¹ and RB² are independently of each other H, C₁₋₆ alkyl,C₃₋₆ cycloalkyl,ORC C (3DO) N (RC)OC (3DO) N (RC)C (3DO) ORC OC (3DO) ORC nitro trifluorometilo trifluorometoxi alcoxi CC₁₋₆ thioalkoxy,N (RC)5 to 7 membered heterocyclyl or 5 to 7 membered heteroaryl, or C₆₋₁₀ aryl；RC is independently in each case H or C₁₋₆ alkyl,The wavelength line represents the connection point of X and formula carbon (1), which is connected to X； or X is 0.83222；； h, ch8322；； co8322；, h, C (= O) nhch8322； (= O) h, ch83222； (= O) h, ch8322； (= O) n (H) ch (r8311b (ORB 3) (ORB 83080808)；Or other formula (4),where R⁷ is H, methyl, ethyl, or -CH₂OH； or R⁷ and RB³ together wit
