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СПОСОБ ПОЛУЧЕНИЯ КОМПОЗИТА ЛЕКАРСТВЕННОГО СРЕДСТВА И БЛОК-СОПОЛИМЕРА И ФАРМАЦЕВТИЧЕСКИЙ ПРЕПАРАТ, СОДЕРЖАЩИЙ ЕГО
专利权人:
НИППОН КАЯКУ КАБУСИКИ КАЙСЯ (JP)
发明人:
МОТОЯМА Дзун (JP)
申请号:
RU2013114481/15
公开号:
RU2013114481A
申请日:
2011.08.31
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of forming a composite of a medicament and a block copolymer, the process comprising: mixing the poorly water soluble drug and a block copolymer comprising a hydrophilic segment and a hydrophobic segment, linked together in one or more nonaqueous solvents optional heating of the mixture spraying the resulting liquid isushku smesi.2. A method according to Claim. 1, where the liquid mixture containing poorly water soluble drug and a block copolymer is heated and the liquid mixture was spray dried in the ambient environment of the gas flow, maintained at a temperature equal to or lower than the melting temperature of the block copolymer. 3. A method according to Claim. 1 or 2, wherein the liquid mixture containing poorly water soluble drug and a block copolymer is heated to a temperature of 25 ° C or vyshe.4. A method according to Claim. 1 or 2, wherein the liquid mixture containing poorly water soluble drug and a block copolymer is heated to a temperature of 35 ° C or vyshe.5. A method according to claim. 2, where the environment is a gas stream used for spray-drying is at a temperature of 40 ° C or nizhe.6. A method according to claim. 2, where the environment is a gas stream used for spray-drying is at a temperature of 20 ° C or nizhe.7. A method according to any one of claims. 1, 2, 5 and 6, wherein the proportion of components other than non-aqueous solvent in the liquid mixture containing poorly water soluble drug and a block copolymer is 10 wt.% Or greater based on the total weight of the liquid smesi.8. A method according to any one of claims. 1, 2, 5 and 6, wherein poorly water-soluble drug is a poorly water-soluble anticancer agent, agent1. Способ получения композита лекарственного средства и блок-сополимера, способ включает:смешивание плохо растворимого в воде лекарственного средства и блок-сополимера, содержащего гидрофильный сегмент и гидрофобный сегмент, связанные вместе, в одном или нескольких неводных растворителяхнеобязательный нагрев смеси
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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