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BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY
专利权人:
Julia Zimmer;Carsten Reissner;Petra Seemann;Stefan Mundlos;Georg Duda
发明人:
Petra Seemann,Stefan Mundlos,Carsten Reissner,Georg Duda,Julia Zimmer
申请号:
US13255909
公开号:
US20120058944A1
申请日:
2010.03.11
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
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中国工程科技知识中心
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http://www.ckcest.cn/home/
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