A power injector syringe assembly (170) is disclosed. The assembly (170) includes a coupling (130&prime) and a syringe cradle (180) that extends from the coupling (130&prime). The coupling (130&prime) and cradle (180) may be integrally formed. In any case, the coupling (130) includes a wedge-shaped mounting flange (144) to facilitate installation of the assembly (110) on a syringe mount (200) of a power injector. The coupling (130) also includes at least one coupling member (150) to facilitate removal of the assembly (110) from the syringe mount (200). At least one part (186) of the cradle (180) extends no more than 180° about a long axis (176) of the cradle (180), while a syringe retention section (188) of the cradle (180) does extend more than 180° about this long axis (176).
