Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.本文闡述與包括抗體在內之結合人類ST2之抗原結合蛋白質有關的組合物及方法。在特定實施例中，本發明提供完全人類抗ST2抗體以及其衍生物及變體。進一步提供編碼此等抗體及抗體片段、變體及衍生物之核酸。此外，提供製備及使用此等抗體之方法，包括治療及預防自體免疫及發炎性病症之方法。
