Declarationsunder Rule .17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) in black and white； the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (51) International Patent Classification: CO7D 413/14 (2006.01) A61K 9/48 (2006.01) A61K 31/5377 (2006.01) A61P 25/28 (2006.01) (21) International Application Number: PCT/IB2018/050314 (22) International Filing Date: 18 January 2018 (18.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17152481.2 20 January 2017 (20.01.2017) EP (1) O C F F N NH 2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIP0 I PCT omit VIII °nolo 01110111 Ho Him No oimIE (10) International Publication Number WO 2018/134761 Al (71) Applicant: NOVARTIS AG [CH/CH]； Lichtstrasse 35, 4056 Basel (CH). (72) Inventor: RAMOS, Rita； Novartis Pharma AG, Postfach, 4002 Basel (CH). (74) Agent: NOVARTIS AG； Lichtstrasse 35, 4056 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM,
