BLANCHETOT, CHRISTOPHE,SMIT, MARTINE,LEURS, REGORIUS,JAEHNICHEN, SVEN,SAUNDERS, MICHAEL JOHN SCOTT,DE HAARD, JOHANNES JOSEPH WILHELMUS,VANLANDSCHOOT, PETER
申请号：
CA2724208
公开号：
CA2724208C
申请日:
2009.05.18
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to amino acid sequences that are directedagainst (as defined herein) G-protein coupledreceptors (GPCRs) and in particular to CXCR4 and CXCR7, as well as tocompounds or constructs, and in particular proteinsand polypeptides, that comprise or essentially consist of one or more suchamino acid sequences (also referred to herein as"amino acid sequences of the invention", "compounds of the invention", and"polypeptides of the invention", respectively).Furthermore, the invention provides a new method of making amino acidsequences that are directed against transmembrane protein,and in particular for multiple spanning transmembrane proteins for which thenative conformation cannot be reproduced in other"in vitro" system (e.g. GPCRs in general).
