Being method in order to decrease the number of antibodies where the inside of the blood of the suffering body is selected, the fact that it makes the blood pass with the fact that you take the blood from the suffering body and alongside the passage which is surrounded it had, the passage, the surface provided with the semi- permeable hollow fiber of one or more which possesses the membrane of one or more which is positioned substantially vertically vis-a-vis the length of the hollow fiber of one or more and the unique antigen for the antibody which is locked to the membrane of one or more, furthermore, had the fact that the processing being completed blood is reset to the internal circulation of the suffering body, may be reset as for the processing blood,By comparison with before the processing, the number of antibodies which are selected has decreased.被験体の血液中の選択された抗体の数を減らすための方法であって、被験体から血液を取ることと、囲まれた通路に沿って血液を通過させることとを備え、通路は、表面が1つ以上の中空ファイバの長さに対して実質的に垂直に位置決めされた1つ以上の膜を有する1つ以上の半透過性中空ファイバと、1つ以上の膜に固定された抗体に特異的な抗原とを備え、さらに、処理済み血液を被験体の内部循環に戻すことを備え、戻された処理済み血液は、処理前と比較して、選択された抗体の数が減っている。