The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating, regenerating, repopulating injured Nucleus Pulposus cells/tissue, notochord derived tissue, and/or tissue whose formation is guided by notochordal cells, e.g. spinal intervertebral disc and/or central nervous system such as spine.
