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USE OF LHAT FOR TREATING ANEMIA AND DYSFUNCTION OF RED BLOOD CELLS
专利权人:
АЛЬФАКОР ФАРМА ЭлЭлСи (US)
发明人:
АУЕРБАХ Брюс (US),КРАУС Брайан (US),ХОМЭН Рейнолд (US)
申请号:
RU2012100778/15
公开号:
RU2012100778A
申请日:
2010.06.14
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of treating a patient having a condition characterized by anemia or dysfunction of red blood cells, comprising administering to the patient a therapeutically effective amount of an agent that increases either the activity of LHAT or the level of LHAT in plasma or has both effects. The method according to claim 1, where the agent is LHAT. 3. The method according to claim 1, where the agent is a drug that increases the activity or level of endogenous LHAT. The method of claim 1, wherein the agent is a gene therapy vector. The method according to claim 2, where the amount of LHAT is an amount that increases the concentration of LHAT to a level exceeding the normal level of LHAT, or the activity of LHAT to a level exceeding the normal activity of LHAT. The method of claim 5, wherein the condition is characterized by red blood cells with reduced deformability, reduced oxygenation, increased aggregation and adhesion, decreased nitric oxide function, reduced lifespan, or any combination of the above phenomena. The method of claim 5, wherein the condition is anemic. The method of claim 5, wherein the condition is sickle cell disease, diabetes, thalassemia, rheumatoid disease, autoimmune disease, arthritis, liver disease, cirrhosis, hepatitis, acanthocytosis, sepsis, dementia, anemia or microvascular disorder, inflammatory disease, parasitic disease , erectile dysfunction, cancer, preeclampsia, critical illness or injury. 9. The method of claim 8, wherein the inflammatory disease is sepsis, rheumatoid disease, anemia of inflammation, or inflammation after surgery. How1. Способ лечения пациента, имеющего состояние, характеризующееся анемией или дисфункцией красных кровяных клеток, включающий в себя введение пациенту терапевтически эффективного количества агента, который увеличивает либо активность ЛХАТ, либо уровень ЛХАТ в плазме или оказывает оба эффекта.2. Способ по п.1, где агентом является ЛХАТ.3. Способ по п.1, где агентом является лекарство, увеличивающее ак
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