Marc Bellotti,H. Bryan Brewer,Hassibullah Akeefe,Adam Paul Conner,Timothy Jon Perlman
申请号：
US16003926
公开号：
US20180355021A1
申请日:
2018.06.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
