Mary S. Rosendahl,Sankaram B. Mantripragada,Eliana B. Gomez
申请号：
US16032952
公开号：
US20180318429A1
申请日:
2018.07.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein-PEG conjugate. The method may further include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein-PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity-PEG conjugate salt.
