METHOD FOR MEASURING CELL-TO-CELL TRANSMISSION OF ALPHA-SYNUCLEIN AGGREGATES USING BIMOLECULAR FLUORESCENCE COMPLEMENTATION SYSTEM AND METHOD FOR SCREENING A SUBSTANCE FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASE USING THE SAME
The present disclosure relates to dual-cell model and Caenorhabditis elegans model systems for measuring neuron-to-neuron transmission of protein aggregates, and more particularly to transgenic cell and animal model systems expressing fusion proteins of N-terminus or C-terminus of fluorescent proteins with α-synuclein proteins, methods for measuring continuous cell-to-cell transmission of α-synuclein aggregates using the same, and methods for screening substances for preventing or treating neurodegenerative diseases.
