According to the invention, zerumbone is used for a slimming topical treatment. Zerumbone is preferably extracted from Zingiber zerumbet (L.) Smith.In addition according to the invention zerumbone can be combined with an agent that mimics the beneficial effects of caloric restriction via a hormetic response, preferably a Globularia cordifolia extract,and/or a lipolytic additional active agent, preferably from the methylxanthine family, including caffeine, theophylline, theobromine or aminophylline.