Their pharmaceutical use and spiro derivatives novel applications of useful adhesion molecule inhibitors have been disclosed for the treatment of inflammatory disease in particular. For example the spiro derivatives of the present invention has a chemical structure represented by the following formula (31).新規なスピロ誘導体及びその医薬用途、とりわけ炎症性疾患の治療に有用な接着分子阻害剤としての用途が開示されている。本発明のスピロ誘導体は、例えば下記式(31)で示される化学構造を有する。