E3 LIGASE INHIBITORS

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专利权人:

Brent R. Stockwell

发明人:

Brent R. Stockwell,Ariel Herman

申请号：

US13256680

公开号：

US20120135089A1

申请日:

2010.03.17

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention provides, e.g., compounds having the structure of formula (I): The present invention also provides pharmaceutical compositions that include such compounds, and methods for modulating murine double minute 2 protein (Mdm2) E3 ligase activity, particularly the Mdm2-MdmX hetero-complex E3 ligase activity, using such compounds.

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