SASU, Barbra Johnson,DETTLING, Danielle Elizabeth,SOMMER, Cesar Adolfo,YEUNG, Yik Andy,HAMZE, Moustafa Marc
申请号：
PH12019502637
公开号：
PH12019502637A1
申请日:
2019.11.22
申请国别(地区):
PH
年份:
2020
代理人:
摘要：
Provided herein are antibodies that specifically bind to Fms-like tyrosine kinase 3 (FLT3), chimeric antigen receptors (CARs) that specifically bind to FLT3, and engineered immune cells expressing such CARs (e.g. FLT3-specific CAR-T cells). The invention also provides making such antibodies, CARs, and engineered immune cells. The invention also provides using such antibodies, CARs, and engineered immune cells, for example for the treatment of a condition associated with malignant cells expressing FLT3 (e.g., cancer).
