The present invention provides a neural sensing device with interference suppression, including: an array of sensing units, a control signal generator and a signal processing module. The array of sensing units includes a plurality of sensing units. Each of the sensing units is configured to generate a sensing signal. The control signal generator is connected to the array of sensing units and is configured to generate a control signal to a surrounding of each of the sensing units. A signal strength of the control signal is lower than a signal strength of the sensing signals, so the control signal is isolated between the sensing signals between each of the sensing units, thereby suppressing interference. The signal processing module is connected to the array of sensing units and the control signal generator. The signal processing module generates and outputs a processing signal to at least one neuron.