Embodiments facilitate generation of a prediction of long-term survival (LTS) or short-term survival (STS) of Glioblastoma (GBM) patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for LTS or STS based on a radiographic-deformation and textural heterogeneity (r-DepTH) descriptor generated based on radiographic images of tissue demonstrating GBM. A second set of embodiments discussed herein relates to determination of a prediction of disease outcome for a GBM patient of LTS or STS based on an r-DepTH descriptor generated based on radiographic imagery of the patient.
