Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them
Mark Richard Stewart;Trevor Robert Perrior;Gary Karl Newton;Rehan Aqil
发明人:
Trevor Robert Perrior,Gary Karl Newton,Mark Richard Stewart,Rehan Aqil
申请号：
US13811164
公开号：
US08962609B2
申请日:
2011.07.18
申请国别(地区):
US
年份:
2015
代理人:
摘要：
C Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases associated with aberrant activity of the protein kinases IKKε and/or TBK-1: in which: R1 represents an aliphatic heterocyclyl group having 4, 5, 6 or 7 ring atoms, bonded to the phenyl group shown in formula I through a ring nitrogen atom, and optionally substituted by one or more substituents defined in the Specification； R2 represents a phenyl or heteroaryl group which is optionally substituted by one or more substituents defined in the Specification； and each of R3 and R4 independently represents a hydrogen atom or a C1-4 alkyl group.
