Weight loss compositions and systems are disclosed that may include various combinations of essential oils and other components, which may be effective in promoting weight loss. Some implementations may include a fat blocker, a filler component, an insulin sensitizer, and a fat growth suppressant. In some instances, the fat blocker may include a carotenoid. In other instances, the fat blocker may be selected from the group consisting of fucoxanthin and punicic acid. A weight loss composition may include a first component and a second component, wherein the combination of the first and second components may be effective in promoting weight loss. The first element may include a fat blocker, a filler component, and a first insulin sensitizer. The second element may comprise a fat growth suppressant and a second insulin sensitizer.