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ABGABE VON THERAPEUTISCHEN RNAS ÜBER ARRDC1-VERMITTELTE MIKROVESIKEL
专利权人:
President and Fellows of Harvard College
发明人:
LU, Quan
申请号:
EP17859007
公开号:
EP3518981A4
申请日:
2017.10.03
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
Methods, systems, compositions and strategies for the delivery of RNA into cells in vivo, ex vivo, or in vitro via ARMMs are provided. In some aspects, ARMMs containing fusion proteins of ARRDC1 fused to an RNA binding protein or an RNA binding protein fused to a WW domain are provided. In some aspects, ARMMs containing binding RNAs associated with cargo RNAs are provided. In other aspects, cargo RNAs associated with a binding RNA, such as a TAR element, are loaded into ARMMs via ARRDC1 fusion proteins containing an RNA binding protein, such as trans-activator of transcription (Tat) protein.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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