LI, DAVID YUNZHI,李云志,李雲志,WANG, JIABING,王家宾,王家賓,YANG, ZHENFAN,杨振帆,楊振帆,ZENG, QINGBEI,曾庆北,曾慶北,ZHANG, XIAOLIN,张小林,張小林
申请号：
TW103107724
公开号：
TWI543977B
申请日:
2014.03.06
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof: which possess inhibitory activity against activating mutant forms of EGFR, and are accordingly useful for their anti-cancer activity and in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of the compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.本發明係關於式(I)化合物或其醫藥上可接受之鹽:其對EGFR之活化突變形式具有抑制活性,且因此可用於其抗癌活性及治療人類或動物體之方法。本發明亦係關於製造該等化合物或其醫藥上可接受之鹽之方法、含有其之醫藥組合物及其用於製造用以在恆溫動物(例如人類)中產生抗癌效應之醫藥上之用途。
