Phosphorodiamidate backbone linkage for oligonucleotides

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专利权人:

Geron Corporation

发明人:

Krisztina Pongracz,Mahesh Ramaseshan

申请号：

US14498872

公开号：

US09708360B2

申请日:

2014.09.26

申请国别(地区):

US

年份:

2017

代理人:

摘要：

This invention relates to antisense oligonucleotides comprising at least one N3′→P5′ phosphorodiamidate linkage (NPN) in the backbone, and kits and pharmaceutical compositions thereof, useful for modulating gene expression involved in the pathogenesis of a disease. Also included are compounds useful as building blocks of said antisense oligonucleotides and methods of preparing said antisense oligonucleotides and building block compounds including NPN linkages.

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