THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;NOVARTIS AG
发明人:
GILL, SAAR,RUELLA, MARCO,KLICHINSKY, MICHAEL
申请号：
CA3032581
公开号：
CA3032581A1
申请日:
2017.08.01
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of an antigen, e.g., a solid tumor antigen or antigen expressed on a tumor associated with TAMs and/or MDSCs, by administering a recombinant T cell comprising a CAR binding to said antigen, as described herein, in combination with an inhibitor of a pro-M2 macrophage molecule, e.g., described herein. The invention also provides kits and compositions described herein.
