William H. Frey, II,Samuel Scott Panter,Leah Ranae Bresin Hanson
申请号：
US14063208
公开号：
US20140179790A1
申请日:
2013.10.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods for treating the animal central nervous system for the effects of traumatic brain injury. Therapeutic agents are administered to the upper third of the nasal cavity to bypass the blood-brain barrier and access the central nervous system directly to avoid unwanted and potentially lethal side effects. Therapeutic agents include those substances that interact with iron and/or copper such as iron chelators, copper chelators, and antioxidants. A particular example of such therapeutic agents is the iron chelator deferoxamine (DFO). An effective amount of DFO may be administered to the upper third of the nasal cavity of a patient suffering from traumatic brain injury. The effective amount of DFO is delivered directly to the patients central nervous system for treating the traumatic brain injury.
