Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2'3-cGAMP, 2'2-cGAMP, 3'2'-cGAMP and 3'3'-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics.La sintasa de GMP-AMP-cíclica (cGAS) y la GMP-AMP-cíclica (cGAMP), incluyendo 2'3'-cGAMP, 2'2'-cGAMP, 3'2'-cGAMP y 3'3'-GAMP, se utilizan en formulaciones farmacéuticas (incluyendo adyuvantes de vacunas), rastreos de fármacos, terapias y diagnósticos.