COMPOSE DE [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE, SON PROCEDE DE PREPARATION ET SON UTILISATION

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专利权人:

CHINESE ACADEMY OF SCIENCES;SHANGHAI INSTITUTE OF MATERIA MEDICA

发明人:

DUAN, WENHU,GENG, MEIYU,CHEN, FANG,AI, JING,CHEN, YI,ZHAN, ZHENGSHENG,LV, YONGCONG,WANG, YING,DING, JIAN

申请号：

CA2820389

公开号：

CA2820389A1

申请日:

2011.12.08

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compound represented by formula (I) or formula (II), a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate or solvate thereof. Also related to a preparation method of the compound, a pharmaceutical composition comprising an effective amount of the compound, as well as use of the compound as a protein tyrosine kinase inhibitor, particularly as a c-Met inhibitor, in the preparation of a medicament for the prevention and/or treatment of diseases associated with c-Met abnormality.

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http://www.ckcest.cn/home/