Crooke, Stanely T.,Baker, Brenda,Eldrup, Anne B.,Manoharan, Muthiah,Bhat, Balkrishen,Griffey, Richard,Swayze, Eric E.,Prakash, Thazha P.
申请号：
AU2010201712
公开号：
AU2010201712B2
申请日:
2010.04.29
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010201712B220120531.pdf#####ABSTRACT Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a 5 portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2' substituent group on a sugar moiety that is not H or OH. 10 Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.
