Provided are methods for preventing and treating inflammation and organ injuryafter ischemia/reperfusion, and methods for treating lung injury, comprisingadministering a milk fat globule epidermal growth factor-factor VIII (MFG-E8)to a subject. Also provided are pharmaceutical compositions comprising MFG-E8in dosage form for preventing and treating inflammation and organ injury afterischemia/reperfusion, and for treating lung injury, and methods of preparinga pharmaceutical composition for preventing and treating inflammation andorgan injury after ischemia/reperfusion, and for treating lung injury, comprisingformulating MFG-E8 in a pharmaceutical composition.