The present embodiment is related to multi-dose antigen driving dendritic cells (DC) vaccine of the injectable of FDA certifications. In one embodiment, active antigen load DC vaccines include initial immunizing dose and multiple " booster " dosage. Provide simultaneously it is a kind of for all block she -2 and she -3 as the treatment caused in terms of permanent lump aging -2 expression breast cancer in her. The calling inoculation of the combination anti-estrogen therapy and anti-HER2 dendrons for ERpos/HER2pos DCIS patient with breast cancers is provided simultaneously.