The present invention relates to a wheelchair brake assembly (10) comprising a seat brake system (20) and a wheel frame brake system (30). The seat brake system (20) and the wheel frame brake system (30) are separable from each other. The seat brake system (20) comprises a caregiver brake lever (21) and an actuating member (22), the caregiver brake lever (21) being coupled to the actuating member (22). The wheel frame brake system (30) comprises a brake transmission assembly (35), a first brake mechanism (38) and a second brake mechanism (39) which are adapted to be provided on a first wheel (40) and a second wheel (41) of the wheelchair respectively. The brake transmission assembly (35) is coupled to the first brake mechanism (38) and the second brake mechanism (39). The brake transmission assembly (35) comprises an actuating lever (31) having a first free end (32) and a second end (33). The second end (33) is coupled to the first brake mechanism (38) and the second brake mechanism (39). The actuating lever (31) is rotatable about an axis (A) perpendicular to the longitudinal extension of the actuating lever (31) and located between the first free end (32) and the second end (33) of the actuating lever (31), wherein the actuating member (22) is adapted to operate on the first free end (32) of the actuating lever (31) to cause the actuating lever (31) to rotate.La présente invention concerne un ensemble frein de fauteuil roulant (10) comprenant un système de frein de siège (20) et un système de frein de cadre de roue (30). Le système de frein de siège (20) et le système de frein de cadre de roue (30) sont séparables l'un de l'autre. Le système de frein de siège (20) comprend un levier de frein (21) pour personnel soignant et un élément d'actionnement (22), le levier de frein pour personnel soignant (21) étant accouplé à l'élément d'actionnement (22). Le système de frein de cadre de roue (30) comprend un ensemble de transmission de frein (35), un premier mécanisme de