SUN, Jeonghoon,TAM, Lei-ting Tony,HAN, Hq,KWAK, Keith Soo-nyung,ZHOU, Xiaolan
申请号：
ES08742032
公开号：
ES2613043T3
申请日:
2008.03.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
An isolated protein comprising a variant activin IIB receptor polypeptide (vActRIIB), wherein said polypeptide is selected from the group consisting of: (a) a polypeptide having the polypeptide sequence set forth in SEQ ID NO: 18, except by a single amino acid substitution at position 28, wherein the substitution is selected from any one of E by A, F, Q, V, I, L, M, K, H, W and Y； (b) a polypeptide having the polypeptide sequence set forth in amino acids 19 to 134 of SEQ ID NO: 18, except for a single amino acid substitution at position 28, wherein the substitution is selected from any one of E by A, F, Q, V, I, L, M, K, H, W and Y； (c) a polypeptide having the polypeptide sequence set forth in amino acids 23 to 134 of SEQ ID NO: 18, except for a single amino acid substitution at position 28, wherein the substitution is selected from any one of E by A, F, Q, V, I, L, M, K, H, W and Y； (d) a polypeptide having the polypeptide sequence set forth in amino acids 25 to 134 of SEQ ID NO: 15 18, except for a single amino acid substitution at position 28, wherein the substitution is selected from any one of E by A, F, Q, V, I, L, M, K, H, W and Y； (e) a polypeptide having at least 90% identity with any one of (a) to (d), in which the substitution at position 28 is selected from any one of E by A, F, Q, V , I, L, M, K, H, W and Y, and in which the polypeptide is capable of binding to myostatin, activin A or GDF-11.Una proteína aislada que comprende un polipéptido receptor de activina IIB variante (vActRIIB), en la que dicho polipéptido se selecciona entre el grupo que consiste en: (a) un polipéptido que tiene la secuencia polipeptídica expuesta en la SEQ ID NO: 18, excepto por una única sustitución de aminoácido en la posición 28, en el que la sustitución se selecciona entre una cualquiera de E por A, F, Q, V, I, L, M, K, H, W e Y； (b) un polipéptido que tiene la secuencia polipeptídica expuesta en los aminoácidos 19 a 134 de la SEQ ID NO: 18, excepto por una única sustituci
