베나탈, 비달,르레부르즈-피게오니에르, 가이,탈디프, 쟝-끌로드,토린, 에릭,레아움, 에릭
申请号：
KR1020100083962
公开号：
KR1013599360000B1
申请日:
2010.08.30
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
Ivabradine (3-(3-(((7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl)methylamino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-bennzazepin-2-one) is used to prepare a medicament for treating endothelial dysfunction. ACTIVITY : Cardiant； Antilipemic； Antidiabetic； Hypotensive； Antiarteriosclerotic； Neuroprotective； Cerebroprotective； Nootropic. Rats with cardiac insufficiency were treated with (I) at a daily dose of 10 mg/kg for 3 months. This prevented endothelial dysfunction in the coronary, renal and cerebral arteries, the dilation of these arteries being similar to that of healthy animals. MECHANISM OF ACTION : None given.본 발명은 내피 기능장애를 치료하는 약제를 수득하기 위한, 이바브라딘, 또는 3-{3-[{[(7S)-3,4-디메톡시바이시클로[4.2.0]옥타-1,3,5-트리엔-7-일]-메틸}-(메틸)-아미노]-프로필}-7,8-디메톡시-1,3,4,5-테트라히드로-2H-3-벤즈아제핀-2-온, 이의 약제학적으로 허용되는 산과의 부가염 및 이들의 수화물의 용도에 관한 것이다.
