Sense oligonucleotide having iNOS expression control action and composition containing the same

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专利权人:

学校法人関西医科大学;株式会社アミノアップ化学

发明人:

奥村 忠芳,西澤 幹雄,上山 泰男,若命 浩二,三浦 健人

申请号：

JP2008520621

公开号：

JP5466402B2

申请日:

2007.06.07

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.

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