YI, KYU YANG,이규양,LIM, CHAE JO,임채조,SUH, JEE HEE,서지희,KIM, SOO HEE,김수희
申请号：
KR1020110106962
公开号：
KR1020130042847A
申请日:
2011.10.19
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A novel phthalazinone derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable composition containing the same for preventing or treating MCH receptor 1-related diseases are provided to prevent or treat obesity, diabetes, metabolic disorders, anxiety, and depression.CONSTITUTION: A novel phthalazinone derivative and a pharmaceutically acceptable salt thereof are denoted by chemical formula 1. An MCH receptor-1 antagonist contains the phthalazinone derivative or a pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for preventing or treating MCH-related diseases contains the phthalazinone derivative and a pharmaceutically acceptable salt thereof as active ingredients. The MCH-related diseases are selected from the group consisting of obesity, diabetes, metabolic disorders, anxiety, and depression.COPYRIGHT KIPO 2013본 발명은 신규한 프탈라지논 유도체 및 그의 MCH 수용체-1 관련 질환에 대한 치료학적 용도에 관한 것이다. 본 발명에 의한 신규한 프탈라지논 유도체는 MCH(멜라닌 농축 호르몬) 수용체에 대한 길항제로 작용함으로써 MCH가 MCH 수용체에 결합함으로써 유발되는 비만, 당뇨병, 대사장애, 불안증 및 우울증과 같은 MCH 관련 질환을 예방 또는 치료하는데 유용하게 사용할 수 있다.
