The present invention relates to a combined norovirus and rotavirus vaccine for prevention of norovirus and rotavirus infection and/orviral induced diarrheal and vomiting dis easesin man. More specifically the invention comprises a method ofpreparing combination vaccine compositions comprising norovirus and rotavirus antigens in particular mixtures of norovirus VLPs and rotavirus recombinant VP6 protein or double layered VP2/VP6 VLPs. In addition the invention relates to methods of inducing an immune re sponse.
