The present disclosure provides systems for heat source, e.g., data center, cooling and aquaculture. In certain aspects, the systems include a heat source, e.g., data center, having a water cooling subsystem configured to receive cool water and output warm water and an aquaculture center co-located with the heat source, e.g., data center, and configured to receive the warm water. Aspects of the invention also include methods for cooling a heat source, e.g., data center, using a water cooling subsystem and cultivating aquatic organisms with an aquaculture center that is co-located with the heat source, e.g., data center.