THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
DEISSEROTH, KARL,YIZHAR, OFER,GUNAYDIN, LISA,HEGEMANN, PETER,BERNDT, ANDRE
申请号：
CA2743666
公开号：
CA2743666C
申请日:
2009.11.13
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Stimulation of target cells using light, e.g., in vivo or in vitro, isimplemented using a variety of methods andde-vices. One example involves a vector for delivering a light-activatedmolecule comprising a nucleic acid sequence that codes forlight-activated molecule. The light-activated molecule includes a modificationto a location near the all- trans retinal Schiff base,e.g., to extends the duration time of the open state. Other aspects andembodiments are directed to systems, methods, kits,compositions of matter and molecules for ion channels or pumps or forcontrolling currents in a cell (e.g., in in vivo and in vitroenviron-ments).
