The Rockefeller University;Icahn School of Medicine at Mount Sinai
发明人:
COLLER, Barry S.,FILIZOLA, Marta,FOLEY, Michael Andrew
申请号：
EP17824775
公开号：
EP3481814A4
申请日:
2017.07.05
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
2-Substituted-4-(5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanamido)butanoic acids are disclosed. These compounds selectively inhibit αVβ3 without activating the αVβ3 receptor. They are useful for treating osteoporosis, acute myelogenous leukemia, sickle cell disease, focal segmental glomerulosclerosis, fibrosis, supravalvular aortic stenosis associated with Williams syndrome, tumors expressing αVβ3, tumor metastasis, bone resorption, T-cell lymphoma, retinal disease, age-related macular degeneration, diabetic retinitis, and herpes simplex virus infection. They may also be used for inhibiting tumor angiogenesis.
