The J. David Gladstone Institutes; A Testamentary Trust Established under The Will of J. David Gladstone
发明人:
SRIVASTAVA, Deepak,ANG, Yen-Sin
申请号：
EP17821102
公开号：
EP3474868A4
申请日:
2017.06.27
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present disclosure provides the development of engineered cardiomyocytes having mutations in transcription factor involved in vivo with cardiac development and/or function. These cell populations comprise mutations that are associated with deleterious effects in vivo in mammals. The mutations of the engineered cardiomyocytes of the disclosure thus are rationally designed based on demonstrated physiological effects in mammals, e.g., mice or humans.
