LAQUERRE, SYLVIE,DUMBLE, MELISSA,LEBOWITZ, PETER F.,KUMAR, RAKESH
申请号：
PE0005022012
公开号：
PE10932012A1
申请日:
2010.10.15
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a combination comprising a MEK Inhibitor such as n - (3 - [3 - (2 - cyclopropyl - 5 - fluoro - Iodine - 4 - phenyl - 6.8 - Dimethyl amino) - - - - - 2,4,7 trioxo 3,4,6,7 pirido - tetrahydro - 2H - [4,3-d] - pyrimidine - 1 - il] - phenyl) - acetamide (formula I) with a B - Raf inhibitor such as n - (3 - [5 - (2 - amino - 4 - pirimidinil) - 2 - (1,1-dimethyl-ethyl) - 1,3 - thiazol-4-yl] - 2 - fluoro phenyl} - 2.6 - difluoro - bencen sulfonamide (formula II).This combination is useful in the treatment of cancerREFERIDA A UNA COMBINACION QUE COMPRENDE UN INHIBIDOR DE MEK TAL COMO N-{3-[3-CICLOPROPIL-5-(2-FLUORO-4-YODO-FENIL-AMINO)-6,8-DIMETILO-2,4,7-TRIOXO-3,4,6,7-TETRAHIDRO-2H-PIRIDO-[4,3-d]-PIRIMIDIN-1-IL]-FENIL}-ACETAMIDA (FORMULA I) CON UN INHIBIDOR DE B-Raf TAL COMO N-{3-[5-(2-AMINO-4-PIRIMIDINIL)-2-(1,1-DIMETIL-ETIL)-1,3-TIAZOL-4-IL]-2-FLUORO-FENIL}-2,6-DIFLUORO-BENCEN-SULFONAMIDA (FORMULA II). DICHA COMBINACION ES UTIL EN EL TRATAMIENTO DEL CANCER
