1. A method of treating vascular leak syndrome, comprising contacting a subject in need of treatment with an effective amount of a compound having the formula: i) ii) or iii) or a pharmaceutically acceptable salt thereof. A method for treating vascular leakage in a subject with an inflammatory disease, comprising administering to a needy subject an effective amount of a compound having the formula: i) ii) or iii) or a pharmaceutically acceptable salt thereof. 3. The method of claim 2, wherein the inflammatory disease is lupus, sepsis, or inflammatory bowel disease. The method according to claim 2, wherein the level of angiopoietin-2 is used to regulate the course of treatment or select a new course of treatment. A method for selecting a course of treatment for a subject suffering from vascular leakage syndrome, comprising: a) administering to the subject an effective amount of a compound having the formula: i) ii) or iii) or a pharmaceutically acceptable salt thereof； b) monitoring the level of angiopoietin-2 present in the subject's body treatment process； c) interruption of treatment when the level of angiopoietin-2 returns to its normal range. A method of stabilizing the vascular system in a subject infected with a pathogen, comprising administering to the subject an effective amount of a compound having the formula: i) ii) or iii) or a pharmaceutically acceptable salt thereof. 7. The method of claim 6, wherein the pathogen is selected from bacteria, viruses, yeast, fungi, or protozoal. The method of claim 6, further comprising administering to the subject an effective amount of an antibacterial agent, antiviral agent, fungicide, or a combination thereof. The method according to any one of paragraphs. 1-8, where the compound is in the form of a salt with1. Способ лечения синдрома сосудистой утечки, включающий контактирование нуждающегося в лечении субъекта с эффективным количеством соединения, имеющего формулу:i)ii)илиiii)или его фармацевтически приемлемой соли.2
