John Katzenellenbogen;The Board of Trustees of The University of Illinois;The University of Texas Southwestern Medical Center;Zeynep Madak-Erdogan;Philip Shaul;Benita Katzenellenbogen;Sung Kim
发明人:
Katzenellenbogen, John,Katzenellenbogen, Benita,Kim, Sung Hoon,Madak-Erdogan, Zeynep,Shaul, Philip
申请号：
AU2017206060
公开号：
AU2017206060A1
申请日:
2017.01.06
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.
