TOCKER, JOEL,PESCHON, JACQUES, J,FITZPATRICK, DAVID,SMOTHERS, JAMES, F,MEHLIN, CHRISTOPHER,LIM, AI CHING
申请号：
NZ57563107
公开号：
NZ575631A
申请日:
2007.10.01
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is an isolated human monoclonal antibody, comprising a variable heavy chain that is at least 90% identical to SEQ ID NO:14 and a variable light chain that is at least 90% identical to SEQ ID NO:40, wherein said antibody specifically binds human IL-17 receptor A and inhibits the biological activity of human IL-17A. The disclosed antibodies comprise: a. a heavy chain CDR1 comprising an amino acid sequence of X1YGIS, wherein X1 is selected from the group consisting of R, S and G； b. a heavy chain CDR2 comprising an amino acid sequence of WISX1YX2GNTX3YAQX4X5QG, wherein X1 is A, X2 is N, S or K, X3 is N or K, X4 is K or N, and X5 is L or F； c. a heavy chain CDR3 comprising an amino acid sequence of X1QLX2X3DY, wherein X1 is R or K, X2 is Y, V or A, and X3 is F or L； d. a light chain CDR1 comprising an amino acid sequence of RASQSX1X2X3X4LA, wherein X1 is V or I, X2 is I or S, X3 is S or T, X4 is N or S, and X5 is A or N； e. a light chain CDR2 comprising an amino acid sequence of X1X2STRAX3, wherein X1 is G or D, X2 is A or T, and X3 is T or A, and f. a light chain CDR3 comprising an amino acid sequence of QQYDX1WPLT, wherein X1 is N, T or I.
