University of Maryland, Baltimore;National Research Council of Canada
发明人:
James E. Galen,Thanh Pham,Dacie R. Bridge,Jin Yuan Wang,Wangxue C. Chen
申请号：
US16614261
公开号：
US20200179501A1
申请日:
2018.05.15
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.
