Preparation of inactivated artificial antigen-presenting cells and their use in cell therapy农业专利-农业专业知识服务系统

发明人:: カイ，ゼリング,モリアーテイ，アン,デグロー，ジユリ,レテユルク，デイデイエ,シー，ウエイ－シング,ステグマン，カレン・カバト,ユー，シリアン,カイ,ゼリング,モリアーテイ,アン,デグロー,ジユリ,レテユルク,デイデイエ,シー,ウエイ-シング,ステグマン,カレン・カバト,ユー,シリアン

摘要：: Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a psoralen derivative and UVA irradiation.