The present invention relates to an improved method for treating diabetes wherein the improvement comprises administering a PEGylated insulin compound to a patient having moderate to severe chronic kidney disease using an effective amount of the compound.本發明係關於治療糖尿病之改良方法,其中該改良包括使用有效量之聚乙二醇化胰島素化合物向患有中度至嚴重慢性腎臟病之患者投與該化合物。